Big surprise: we _are

Big surprise: we _are_ different

Mark Walport, of Britain’s Wellcome Trust explains the results of CNV (Copy Number Variant) mapping of human DNA.

resistance to infection by HIV, the virus that causes AIDS, is determined in part by multiple copies of the gene CCL3L1, which cannot be seen on an SNP [Single Nucleotide Polymorphism] map

The CNV maps reveal differences which standard and SNP maps miss.

Genes important to the immune system and to brain development and activity tend to have many CNVs, the researchers said.

They picked “1,447 different CNVs that covered about 12 percent of the human genome” of which 285 are associated with diseases.

If it makes that much difference to outright disease, what else might it be changing? And here we are, fussing over trivial differences like blonde hair, skin colour, height & weight, alcohol tolerance, gender... d’oh!

Comments

new life for an old (FTX) PSU, improved life for one human

the LEDs on this 5m strip happen to emit light centred on a red that does unexpectedly helpful things to (and surprisingly deeply within) a human routinely exposed to it. it has been soldered to a Molex connector, plugged into a TFX power supply from a (retired: the MoBo is cactus) Small Form Factor PC, the assorted PSU connectors (and loose end from the strip) have been taped over. the LED strip cost $10.24 including postage, the rest cost $0, the PSU is running at 12½% of capacity, consumes less power than a laptop plug-pack despite running a fan. trial runs begin today.

every-application-is-part-of-a-toolkit at work

I have a LibreOffice Impress slideshow that I wish to turn into a narrated video. 1. export the slideshow as PNG images (if that is partially broken — as at now — at higher resolutions, Export Directly as PDF then use ‘pdftoppm’ (from the poppler-utils package) to do the same). 2. write a small C program (63 lines including comments) to display those images one at a time, writing a config file entry for Imagination (default transition: ‘cross fade’) based on when the image-viewer application (‘display,’ from the GraphicsMagick suite) is closed on each one; run that, read each image aloud, then close each image in turn. 3. run ‘Imagination’ over the config file to produce a silent MP4 video with the correct timings. 4. run ‘Audacity’ to record speech while using ‘SMPlayer’ to display the silent video, then export that recording as a WAV file. 4a. optionally, use ‘TiMIDIty’ to convert a non-copyright-encumbered MIDI tune to WAV, then import that and blend it with the speech (as a quiet b...

boundaries

pushing the actual boundaries of the physical (not extremes, the boundaries themselves) can often remove barriers not otherwise perceived. one can then often resolve an issue itself, rather than merely stonewalling at the physical consequences of the issue.

Plantagenet Penguinista

Search This Blog